Just as against Swiss 20-time Grand Slam champion Federer in Saturday's semi-final, the 21-year-old produced a dashing display of power and guile to stun the in-form Djokovic 6-4, 6-3.
Thirteen-time champion Rafael Nadal, 20-time Grand Slam winner Roger Federer and world number one Novak Djokovic were placed in the same half of the French Open draw on Thursday.
The German world number seven claimed his first ATP crown of the year after besting Canada's Felix Auger-Aliassime 6-3, 6-3 to win the bett1HULKS Indoor title at the same venue last Sunday.
Roger Federer's bid to win a ninth Halle Open title was ended in the semi-final on Saturday by teenage German Alexander Zverev, who defeated the 17-time Grand Slam champion 7-6(4), 5-7, 6-3.
World number five Dominic Thiem heads into Friday's Australian Open semi-final against Alexander Zverev knowing he will have to put their friendship aside to continue his charge towards a maiden Grand Slam title.
The victory over the 19-times Grand Slam champion was the second ATP World Tour Masters 1000 title of the season for the 20-year-old German, who also beat Novak Djokovic in Rome.
Grit, determination, nerves were all on show at the US Open final.
Daniil Medvedev fired Russia into the final of the ATP Cup on Saturday with a tense 3-6, 6-3, 7-5 win over an injury-hampered Alexander Zverev after the German destroyed a racket in frustration over a lost service break.
World number one Novak Djokovic earned his 1,000th tour-level victory by beating Casper Ruud 6-4, 6-3 on Saturday to reach the Italian Open final.
However, the 33-year-old Spaniard will not know until later on Friday whether his Herculean effort was in vain.
Alexander Zverev became the first German to reach the last four at the ATP Finals for 15 years as he beat American John Isner 7-6(5), 6-3 at the O2 Arena on Friday.
Novak Djokovic confirmed he will be coached by Andre Agassi at the French Open after being humbled by German youngster Alexander Zverev in the final of the Italian Open on Sunday.
Novak Djokovic will swiftly overcome the disappointment of failing to win a calendar Grand Slam and a record-breaking 21st major at the U.S. Open, former Yugoslavia Davis Cup coach Radmilo Armenulic said.
Petra Martic kept her composure to advance to the Round of 16
Muguruza wins all-Spanish clash with Badosa at WTA Finals
Second seed Novak Djokovic outclassed Roger Federer in straight sets to enter the final of Australian Open in Melbourne on Thursday. Seven-time champion Djokovic started off slowly before he took complete control to register an emphatic 7-6, 6-4, 6-3 victory in the first semi-final.
The 21-year-old has now recorded victories over all of tennis's so called 'Big Three' this year, having beaten Roger Federer at the Australian Open and Rafa Nadal in Madrid.
Tsitsipas had lost all five previous matches against the Russian, but turned the tables in impressive fashion.
Zverev will have a chance to spoil the birthday party for Nadal, who turns 36 on Friday
IMAGES from Day 5 of the French Open at Roland Garros in Paris on Thursday.
World number one Rafael Nadal has been drawn alongside defending champion Alexander Zverev, Association of Tennis Professionals (ATP) reported.
The victory saw him move up by three places to stand only behind Spain's Rafael Nadal and Swiss star Roger Federer.
Thiem, who also played in the charity event but did not contract the virus, told Austrian media that Kyrgios had "made a lot of mistakes" and should not criticise others.
Images from Day 6 at the French Open, at Roland Garros, in Paris, on Friday.
IMAGES from matches on Day 4 of the US Open at Flushing Meadows in New York on Thursday.
The hosts had blanked Germany in their opening tie and became the first to seal a quarter-final spot with their second 3-0 win in the inaugural team event.
'Generally, I'm happy outside the court, happy on the court, happy in life. Then I think you play your best.'
Djokovic sets sights on Paris Olympics
The 21-year-old German, one of the brightest stars in men's tennis, is yet to progress beyond the quarter-finals at a Grand Slam.
With Federer certain, young Austrian Dominic Thiem is third in the ATP race to London, followed by Stan Wawrinka, Alexander Zverev, Djokovic, world number one Andy Murray, and Belgium's David Goffin.
Carlos Alcaraz came through a testing third round encounter against Nicolas Jarry.
Images from Day 10 of the 2021 US Open in New York on Thursday.
Novak Djokovic is bidding to win the title for the first time since 2015 and equal Roger Federer's six.
Nadal has won the Australian and the French Open back-to-back and has the chance to become the first man to win all four majors in the same year
Dominic Thiem has reached a Grand Slam final three times - only to lose on each occasion
Shapovalov will meet Rafael Nadal for a place in the semi-finals.
World number three Stan Wawrinka beat Roberto Bautista Agut 7-6(8) 6-2 on Saturday and will play Alexander Zverev in the St. Petersburg Open final. The Swiss top seed, playing his first tournament since beating Novak Djokovic to win the U.S. Open title, wore down the Spanish fourth seed Bautista Agut after a tight first set.
Alexander Zverev has proven himself as the best of tennis' new generation of men's players
Japan has extended a state of emergency in Tokyo and three other areas until the end of May as the country battles a surge in COVID-19 cases
Homeland favorite Ashleigh Barty and Serbia's Novak Djokovic are the top seeds for the upcoming Australian Open.
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